[Pablo Alonso]

en respuesta a: GRADE course forum #17827

Dear all,

By now, you should be familiar with how to evaluate the confidence we can place in research results and how to formulate recommendations. We provide you now, with a link to a database of evidence-to-decision frameworks, for you to review some evidence profiles and frameworks
https://guidelines.gradepro.org/search

We also provide two examples below. Please, go to the evidence profile (or summary of findings) initially, and review the reasons the authors include for rating their certainty in the different outcomes. These examples include situations with both clinical trials and observational studies.

Then you can go to the corresponding frameworks to review the judgments panellists made, the recommendations formulated as well as their justification, and other considerations made in the conclusion sections. Within the database you can see other examples, if you are interested. The more you watch, the more you can validate what you are learning.

Example 1:
https://guidelines.gradepro.org/profile/0F91C482-0EC7-18AC-8738-817C23635ED2

Example 2:
https://guidelines.gradepro.org/profile/3A579747-2186-359C-8751-F6245604F25D

Please, do not hesitate to write your reflections or questions.

Pablo Alonso

[Pablo Alonso]

en respuesta a: GRADE course forum #17661

Dear all, very nice to meet you. My name is Pablo Alonso, and I am one of the organizers of the course.

As Javier mentioned, we have prepared a new module with related bibliography for your consideration. A careful read will allow you to start understanding the nuts and bolts of GRADE, mainly on the process of structuring the relevant questions and outcomes, all the way to rating the certainty of evidence.

The module includes 3 articles, about the basics of GRADE and a link to the GRADE handbook, and a resource that Cochrane has assembled, with the most relevant articles and videos of GRADE. The handbook will allow you to clarify most of your doubts, by going straight to what you need, using the Index.

We also attach an article for those of you who have time and interest (no reading is mandatory), to better understand the origins of GRADE. This is an evaluation of some of the main systems for evaluating the quality of evidence carried out by a group of authors from the GRADE group. It reflects the limitations of previous systems and suggests strategies to overcome them.
Atkins, D., Eccles, M., Flottorp, S., et al. Systems for grading the quality of evidence and strength of recommendations I: Critical evaluation of existing approaches. BMC Health Serv Res 4, 38 (2004). https://bmchealthservres.biomedcentral.com/articles/10.1186/1472-6963-4-38

Most of you are now finishing the first 8 modules, during the next few days we will upload the rest of the modules, that will address moving from evidence to recommendations, but also aspects like diagnosis, multiple comparisons or adaptation of guidelines.

We hope you are enjoying the course and look forward to your questions/comments.

Pablo Alonso

[Autor]

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